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KMID : 0356920080550020176
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Korean Journal of Anesthesiology
2008 Volume.55 No. 2 p.176 ~ p.181
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The effects of continuous infusion of ondansetron on postoperative nausea and vomiting in patients receiving IV-patient controlled analgesia following gynecological surgery
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Lim Seung-Mo
Koo Gill-Hoi
Park Sun-Gyoo
Kim Jin-Yun
Kang Hyun
Baek Chong-Wha
Park Jung-Won
Jung Yong-Hun
Woo Young-Cheol
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Abstract
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Background: This study was designed to evaluate the effects of continuous infusion of ondansetron on postoperative nausea and vomiting (PONV) in patients receiving intravenous patient controlled analgesia (IV-PCA) following laparoscopic gynecological surgery.
Methods: Sixty ASA class I and II patients scheduled for gynecological laparoscopic surgery were randomly divided into the following 3 groups that received the specified dosages of ondansetron mixed with IV-PCA: placebo (group 1), ondansetron 8 mg (group 2), ondansetron 16 mg (group 3). The incidences of nausea, vomiting, visual analogue scale (VAS), and side effects were then recorded in the recovery room, 24 h, 48 h and 72 h postoperatively.
Results: There were no significant differences in the occurrence of nausea between group 1 and 2. However, the incidence of nausea in group 3 was significantly lower than in group 1 at 24 h and 48 h after surgery. In addition, significant differences in the occurrence of vomiting were observed among the three groups. However, with the exception of pruritus, no side effects were observed in any of the groups.
Conclusions: IV-PCA mixed with 16 mg of ondansetron effectively prevented nausea at 24 h and 48 h after gynecologic laparoscopic surgery. (Korean J Anesthesiol 2008; 55: 176∼81)
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KEYWORD
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alfentanil, IV-PCA, ondansetron, PONV
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